Product or Service
Profile:Manufacturer - Producer|Ref:PSL146306YH | Country: China | Currency: | Export: No
Product Name: Trilostane
Mol File: 13647-35-3.mol
Packaging Detail: 1kg/tin ; 5kg/tin
Standard Enterprise standard.
DESCRIPTION Trilostane is an inhibitor of isoforms 3β-HSD and 3β-HSD2 of the enzyme 3β-hydroxysteroid dehydrogenase, which plays a role in adrenal steroid biosynthesis. Investigators believe that Arg195 in 3β-HSD versus Pro195 in 3β-HSD2 attributes to the competitive inhibition of 3β-HSD, but not 3β-HSD2 by Trilostane. Research shows that trilostane is effective in suppressing the intracellular production of androstenedione, testosterone, and dihydrotestosterone in LNCaP-FGC prostate cancer cells and inhibiting cortisol biosynthesis in the human adrenal gland. This product serves as a useful tool in steroid biosynthesis research.
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