CAS 70288-86-7 Raw Material Powder Ivermectin for Resistant Parasites /Whatsapp/Skype:+8615308670259
Product Name: Ivermectin
Properties:
-Melting point:157-162
-Solubility in water and organic solvents:
-Easily soluble in toluene, ethyl acetate, ethanol, methanol and the like, its solubility in water is very low
Toxicity
-Acute oral LD50 in rats: 94.3~212.0mg/kg 102.7~194.8mg/kg
-Acute dermal LD50 in rats: 1886.6~4420.4mg/kg 1461.0~3451.0mg/kg
Storage
-Sealed tightly and stored away from light in a cool and dry place
Description
Biological Activity Positive allosteric modulator of the α 7 neuronal nicotinic acetylcholine receptor and the purinergic P2X 4 receptor. Antihelmintic. Also modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM). .
Ivermectin is a new kind of broad spectrum, high efficiency, low toxicity antibiotic drug resistant parasites, external parasite especially are good flooding kill nematodes and arthropods, widely used in cattle, sheep, horses, pigs, gastrointestinal nematodes, lung nematodes and parasitic arthropod, canine intestinal nematodes, ear mites, scabies mites, heart silk worm and microfilariae, gastrointestinal nematodes and external parasites, and poultry
Ivermectin is a semisynthetic, anthelmintic agent for oral administration. Ivermectin is derived from the avermectins, a class of highly active broad-spectrum anti-parasitic agents isolated from the fermentation products of Streptomyces avermitilis. Ivermectin is a mixture containing at least 90% 5-O-demethyl-22, 23-dihydroavermectin A1a and less than 10 % 5-O-demethyl-25-de(1-methylpropyl)-22, 23-dihydro-25-(1-methylethyl) avermectin A1b, generally referred to as 22, 23-dihydroavermectin B1a and B1b or H2B1a and H2B1b, respectively. The respective empirical formulas are C48H74O14 and C47H72O14, with molecular weights of 875.10 and 861.07, respectively.
Ivermectin is a white to yellowish-white, nonhygroscopic, crystalline powder with a melting point of about 155º C. It is insoluble in water but is freely soluble in methanol and soluble in 95% ethanol.
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