Glycyrrhiza uralensis P . E has a long history of medicinal use in Europe and Asia. At high doses, there are potentially severe side effects, including hypertension (high blood pressure), hypokalemia (low blood potassium levels) and fluid retention.Most adverse effects have been attributed to the chemical component glycyrrhiza (or glycyrrhizic acid). Glycyrrhiza uralensis P . E can be processed to remove the glycyrrhiza, resulting in DGL (deglycyrrhizinated licorice), which does not appear to share the metabolic disadvantages of licorice.