Our approach in developing of HEV immunoassays relies on optimizations in the detection techniques and improvements in the quality of antigens and antibodies which we use.
We utilize a recombinant capsid antigen (E2) expressed from the highly conserved region of ORF2 of the HEV. This antigen expresses some important conformation antigenic epitopes of the native virus and shows extremely high reactivity to HEV specific antibodies. With this antigen, we have significantly improved the sensitivity and specificity of our HEV assays.
We have developed four different types of HEV ELISA tests that have multiple applications and can be easily adapted for both clinical diagnosis and scientific research.
