Ketoconazole
Synonym: 3-dioxolan-4-yl)methoxy)phenyl)-,cis-;fungarest;fungoral;ketoconazol;ketoderm;ketoisdin;kw-1414;nizoral
CAS: 65277-42-1
MF: C26H28Cl2N4O4
MW: 531.43
EINECS: 265-667-4
Assay: 99%
Appearance: white powder
Specification: CP
Chemical Property: Melting point 146 Centigrade, insoluble in water
Usage:
- Ketoconazole is a broad-spectrum imidazole antifungal drugs, the market sales of commodity names, mycophenolate Kang Ling gold miconazole and Ning, through cytochrome P-450 highly selective interference with fungal activity, thereby inhibiting the biosynthesis of ergosterol on fungal cell membrane. Ketoxonazole Lotion as skin external use, mainly used for a variety of treatment and prevention of Malassezia caused by infection.
- The skin fungus and yeast fungal skin disease, caused by Trichophyton tinea versicolor and, when local treatment or oral griseofulvin is invalid, severe refractory fungal infection or unacceptable griseofulvin therapy, available for the treatment of.
Pharmacological effects: - Pharmacology of ketoconazole belongs to azole antifungals, deep infection of fungi such as Candida, Fonsecaea, Coccidioides, tissue slurry Pseudomonas, Sporothrix are antibacterial effect, the hair tinea also with antibacterial activity.
- Long term toxicity test showed that the animal toxicology, ketoconazole can make alkaline phosphatase increased significantly, the liver cell degeneration.
Package: 25kg/drum
