Product Name: Pazopanib CAS 444731-52-6
Cas No.: 444731-52-6
Structure:
CAS :444731-52-6
Formula: C21H23N7O2S
Synonyms: 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide;GW 786034;Benzenesulfonamide,5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-;Votrient;
Molecular Weight: 437.52
Boiling Point: 728.814 °C at 760 mmHg
Flash Point: 394.572 °C
Appearance: White powder
Assay: >99.0%
Exterior: White or off white crystal powder
Package: Aluminum bag
Storage: Room temperature
Application: Pazopanib, with its trade name of Votrient, is one kind of potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis. For being one oral angiogenesis inhibitor targeting VEGFR and PDGFR, Pazopanib has been approved for renal cell carcinoma and soft tissue sarcoma. What's more, Pazopanib may also be active in ovarian cancer, and pazopanib also appears effective in the treatment of non-small cell lung carcinoma.
