Now we can supply the Tripterygium Wilfordii Extract with the following specification:
Triptolide 99% Min (HPLC)
Wilforlide A 98% Min (HPLC)
Celastrol 10-98% Min (HPLC)
Tripdiolide 98% Min (HPLC)
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Celastrol is a potent anti-inflammatory that is extracted from the root bark of the Chinese Thunder of God vine (Tripterygium wilfordii Hook) an ivy-like vine in China. Celastrol was used for years as a natural remedy for inflammatory conditions.
It may be useful to minimize inflammation in Alzheimer¡äs disease (AD). Celastrol is a powerful antioxidant, in an isolated rat liver assay of lipidperoxidation, celastrol had a 50% inhibitory cocentration of 7 ¦ÌM, equivalent to about 15 times the antioxidant potency of a-tocopherol.
Scientists have found it to be quite intensely immunosuppressive as well as anti-inflammatory. Celastrol inhibits macrophage activation, MHC I and II processing, TNF-alpha, IL1, IL2, and IL6, it may be developed to be a new anti rheumatoid arthritis(RA) drug.
Triptolide, a diterpene triepoxide, is a purified compound from Tripterygium wilfordii hook F that has been identified as one of the major components responsible for the immunosuppressive and anti-inflammatory effects of this herb. It exists in the extracts of Chinese herb Tripterygium wilfordii hook F, which have been used for more than two centuries in traditional Chinese medicine to treat a variety of autoimmune and inflammatory diseases including rheumatoid arthritis. Recent explorations of the mechanisms of action of triptolide revealed many properties relevant not only to anti-inflammatory activity but also to anticancer activity.
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